In mice. “Their research has demonstrated that drugs blocking this pathway can restore cognitive function in Alzheimer’s mice by improving brain metabolism.”
I know a lot of things are in mice; This is more than that. I wish to point out this passage from the paper as it stands on bioRxiv:
“Here we report that KYN generated by IDO1 suppresses astrocytic lactate transfer to neurons in mouse models
of AD pathology and human iPSC-derived astrocytes from late-onset AD subjects.”
From reading the abstract and editor’s perspective, part of this seems to involve an unfortunate stimulation of kynurenine synthesis from tryptophan, which has deleterious effects on brain cell energy metabolism?
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Open Roles:
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That's tempting, but as long as a standard has design flaws, there will be libraries out there that don't prevent bad configurations, and people (through innocent ignorance) will use them and end up in a bad place.
The whole point of modern cryptography is to take all the oodles of rope to hang yourself with and hand it over to the cryptographers, to leave just the absolute minimum amount of rope with the application developers.
JWT is the opposite of that. It's essentially a reenactment of the bad parts of 90s crypto, including RSA and NONE ciphers.
It'll be really interesting to see where this goes. We currently use Fabric8's Docker Maven Plugin (https://dmp.fabric8.io/) for our Java-based containers. It's a little verbose but works really well- it allows us to run our integration tests directly against the final container images (+ any container dependencies) as part of the standard Maven build.
Your claim and "source" are incoherent nonsense. I regret spending 5m of my life trying to make sense of it and am only writing this comment to help others avoid the same trap.
Not OP, but I'm familiar with a couple primary care providers that don't file insurance claims. It's refreshing to see up-front pricing on their website for services they offer, e.g.: https://www.palmettoproactive.com/services-pricing
I agree! Its great, but lots of people have insurance already so they want to use that to get their primary care, so that 200 dollar visit becomes 40 bucks.
There's nothing inherently political about the this article or the science in general here.
There is, however, a very concerted effort to convince people that the science of climate change 'is political' in order to give those who find the issue uncomfortable license to question the legitimacy of the entire field of study. That's as dangerous as it is absurd, and it's important that it's challenged whenever it's encountered.
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If interested, please send your resume to jobs@apothesource.com.
