You can amend any contract given to you before signing and dating. Simply cross out the sections you do not approve of and initialize the amended sections. I have done this several times with both contract clients and employers and not yet been met with any opposition, but it always went a bit different each time. Every time I advised the employer or client of the contract amendment, sometimes with no detail, sometimes with reasons why. Only once did the customer sign and give me a copy of the amended contract, while in his presence at the office, no questions. All other times the employer or client never sent me a co-signed copy of the contract, but things went forward and I was paid.
As others here have already suggested, I would agree that not signing the given contract and just going forward is not the right approach if you truly want to avoid the non-compete trap. Instead, amend the contract (or have a new contract drafted, as also mentioned earlier) and return it signed; it shows both your commitment to the work, and your attention to detail. The ball is then in their court. YOU now possess an amended, signed and dated copy of THEIR contract, returned to them along with an advisory of amendment.
> This barely scratches the surface. This process, along with others that modify how DNA is folded, brings certain genes closer together (while moving others farther apart), increasing (or decreasing) the likelihood of all sorts of first, second, and third order (...) interactions between them and their products.
> And we've only just begun...
Horribly vague, care to elaborate mathematically or at least provide some study links? The 'DNA folding' you propose begs resolution from some study using quaternions or attractors, or ... ?
Oh heck, me too - since I was responding to your only comment just minutes ago, here is again :)
Maybe, but what is really causing the DNA methylation? The article pins it mostly on epigenetics or environment, the 'stress of space travel', including dietary constraints and oxygen levels all of which are valid.
However, the CNN article only briefly mentions 'radiation' as a factor and likely is lumping that into the 'stressful environment' case repeated several times.
Realistically, cosmic rays or radiation are far more likely to the be prevailing indicator for DNA disruption but are not plainly disclosed here. Despite much research having been done on this specific topic.
Wikipedia states: https://en.wikipedia.org/wiki/Health_threat_from_cosmic_rays
"The potential acute and chronic health effects of space radiation, as with other ionizing radiation exposures, involve both direct damage to DNA, indirect effects due to generation of reactive oxygen species, and changes to the biochemistry of cells and tissues, which can alter gene transcription and the tissue microenvironment along with producing DNA mutations."
From this paper: https://arxiv.org/abs/1406.6641 "In the present paper, we suggest the BNR as a cause of genetic “fails” in living cells, that is one of the possible origins of the so called spontaneous mutations. Cells exposed to the shower of electrons and ions, caused by the collision of a neutron and a proton of water, could be annihilated or experience a permanent damage, in particular, a damage in the DNA."
And more poignantly, from https://www.vencoreweather.com/blog/2017/6/26/1200-pm-cosmic... ( do not read full link if you are easily panicked ): "... there are other consequences of increasing cosmic rays according to “Spaceweather.com” including the penetration of commercial airlines, dosing passengers and flight crews enough that pilots are classified as occupational radiation workers. [Dose rates are expressed as multiples of sea level. For instance, we see that boarding a plane that flies at 25,000 feet exposes passengers to dose rates ~10x higher than sea level. At 40,000 feet, the multiplier is closer to 50x]"
Sorry for the data dump, I just happened to be researching cosmic ray effects the past few evenings and have collected many interesting facts on the topic. The most I have concluded at this point is that humans, as currently derived, are not made for space travel.
I am not a biologist, so my answer may have a mistake ...
Radiation and cosmic rays produce random mutations, where one of the bases of the DNA is changed by another base. (IIRC the radiation breaks the old base, and when the copy or correction enzymes see the mess, they may make a mistake and use the wrong base.)
Methylation is on purpose. Some part of the cell "decides" to enable or disable a gen, and send the correct enzymes to add or remove the methyles in the bases of the specific part of the gene.
(There are also some arm races between bacteria and virus that attack bacteria. The bacteria has an enzyme that split the DNA at points with some specific patterns, to try to kill the virus that enter the cell. The parts of the DNA of the bacteria with this pattern are methylated, so the enzyme doesn't attack the DNA of the owner. https://en.wikipedia.org/wiki/Restriction_modification_syste... )
Maybe, but what is really causing the DNA methylation? The article pins it mostly on epigenetics or environment, the 'stress of space travel', including dietary constraints and oxygen levels all of which are valid.
However, the CNN article only briefly mentions 'radiation' as a factor and likely is lumping that into the 'stressful environment' case repeated several times.
Realistically, cosmic rays or radiation are far more likely to the be prevailing indicator for DNA disruption but are not plainly disclosed here. Despite much research having been done on this specific topic.
Wikipedia states: https://en.wikipedia.org/wiki/Health_threat_from_cosmic_rays
"The potential acute and chronic health effects of space radiation, as with other ionizing radiation exposures, involve both direct damage to DNA, indirect effects due to generation of reactive oxygen species, and changes to the biochemistry of cells and tissues, which can alter gene transcription and the tissue microenvironment along with producing DNA mutations."
From this paper: https://arxiv.org/abs/1406.6641 "In the present paper, we suggest the BNR as a cause of genetic “fails” in living cells, that is one of the possible origins of the so called spontaneous mutations. Cells exposed to the shower of electrons and ions, caused by the collision of a neutron and a proton of water, could be annihilated or experience a permanent damage, in particular, a damage in the DNA."
And more poignantly, from https://www.vencoreweather.com/blog/2017/6/26/1200-pm-cosmic... ( do not read full link if you are easily panicked ): "... there are other consequences of increasing cosmic rays according to “Spaceweather.com” including the penetration of commercial airlines, dosing passengers and flight crews enough that pilots are classified as occupational radiation workers. [Dose rates are expressed as multiples of sea level. For instance, we see that boarding a plane that flies at 25,000 feet exposes passengers to dose rates ~10x higher than sea level. At 40,000 feet, the multiplier is closer to 50x]"
Sorry for the data dump, I just happened to be researching cosmic ray effects the past few evenings and have collected many interesting facts on the topic. The most I have concluded at this point is that humans, as currently derived, are not made for space travel.
They were down for 53 minutes by their reckon and 115 minutes if the OG tweet times are right. Rough split the difference and say 65 minutes downtime, the refund would be ~ $62.50 for a 20 person team bill per month at current rates. That is not too shabby for being out of service for 1 hour during North American primetime. If they were out for 4 hrs 30 mins, it would have been a full refund for the month for everyone!
and you gotta realize the response from the 'band' was most definitely not from Manson et al. but from the same crap ass marketing douche that send the original request.
