Yeah I'm always amazed at what they can get people to pay for individual vials. I buy kits of 24mg reta for ~280. And that's not the cheapest, for certain.
Hasn't this mostly been debunked? You lose muscle mass because you lost mass overall, and whether you lost it too quickly or not is not the major factor. AFAIK maintaining muscle mass while losing fat is borderline impossible for anyone who isn't extremely fat and/or very disproportionate composition to begin with.
Not as far as I know. The ratio of fat-to-muscle loss depends on several factors, most notably the rate of weight loss (see https://pubmed.ncbi.nlm.nih.gov/34371981/). In fact, retatrutide is popular notably because it is known to preserve lean body mass better than other weight loss drugs.
> smoking and alcohol presumably cause way more cases of pancreatitis
Indeed. In fact, I think just recently there were updated studies for at least one of the popular GLP1s that disclaimed entirely a link to pancreatitis.
To be clear I don't think it's actually reasonable to suggest GLP1s should be OTC in 2026. Were that to happen it would be part of a regime change in drug regulation that I'd categorically oppose. The timeline on GLP1s (unlike Zofran) doesn't support it. There are arguments for why your doctors would want to know that you're taking it, and on what schedule. But it should be extremely easy to get.
Agree, it does feel like a class of medication that deserves more control than OTC would provide. I do think it should be largely voluntary, however, with doctors expected to provide it unless there is a specific contraindication that would make it harmful.
Aren't doctors actually exempted specifically from such regulations in almost all states? AFAIK they can actually give nutritional advice legally in nearly every jurisdiction in the US.
FWIW, finnrick's claim to fame is being free. Someone is paying for it. They have also failed blind tests in the past, Janoshik (IIRC) never has. There are several US-based labs but none of them have the same reputation as Janoshik.
Things have changed a little, but during the time that compounding was explicitly allowed, the licensed pharmacies were buying from FDA approved manufacturers, sometimes in China, and sometimes the same manufacturers who also do contract manufacturing for Lilly.
Today ... who knows? It might just be the same gray market stuff us plebes can get.
Won't be anywhere near that. I don't have prices handy, but Lilly sells tirzepatide (a bit better than sema, and usually a bit more expensive) at 500/mo (maybe a bit less now on the trump rx site, I don't recall). Depending on dose, that'll be about 10 bucks a mg give or take. At 50c/mg for sema you were paying a bit of a premium. These days even tirz is only about 30-35c/mg.
I used to buy from Peptide Sciences so I was certainly paying a premium for reputation at $20/mg. I think Semaglutide is now at a bit of a premium due to it falling out of favour and most people switching to Triz and Reta. I only take a low dose and am happy to stick with what's working.
There must be an irony that it was Trumps crackdown on peptides, I presume to prop up his prescription company, that forced me to switch to Chinese supply. By doing it all at once it created a critical mass for that market.
IIRC the biggest impetus for cracking down was Lilly throwing a fit about the gray market supplying reta well before it even becomes available via the normal channels (who knows when that will be). But as you say, it just pushes people to buy direct from Chinese vendors (and it is basically impossible to stop direct imports like that). Would be safer if more reputable US-based sellers could supply it semi-openly as before. Nexaph is still selling it, but I figure the clock is ticking on that.
Weekly, if you are following guidelines correctly. The half-life of most GLP1 peptides is 5-6 days.
I otherwise agree with your point entirely. Though anecdotally, I may have given my brother-in-law a single small vial of tirzepatide at his request so that he could experience it, and the results were ... not good. Turns out he's an idiot, thought that 'more is better', 'drinking enough water is for weenies', and 'I am not an alcoholic even though I get plowed most evenings.' All against my very specific advice on how to give it a try. Whoops.
My fault, yes, I should have realized he was too stupid to do it without adult supervision. He made himself so sick he almost went to the ER. Nothing really dangerous, of course, tirzepatide is pretty safe stuff, but overdosing on it can make you feel very shitty for a few days until the blood concentration drops.
To be fair, most everyone I know who is buying on the gray market considers vendor tests to be minimally required, but still insufficient -- there is no assurance they tested the product they shipped to you. Plan on testing it yourself. I'm sure some people do trust nexaph enough, though, to not worry so much. Whether that trust is well placed, that is a separate discussion.
With most of these you can really tell if they work or not and there is a pretty predicable dose dependent reaction profile. With slow meds like semaglutide you'd maybe not notice it in the first week but you will by week 3. I had mine tested but if that wasn't available I probably would have considered the anecdotal evidence to be sufficient. It appears that most of the scamming is just people taking the money and not shipping anything.
The most dangerous failures I've seen have been sending the wrong peptide. 15 mg of tirzepatide and 15 mg of semaglutide is a very different experience.
After nearly getting hosed in a group buy (I did get refunded, but that is far from a guarantee) because of a product mismatch, I decided to just pay for nexaph. Love him or hate him, his popularity relies on his reputation and he has been more careful than most suppliers to cultivate it with more extensive testing and quality control.
That makes sense, I don't like that the bottles are unlabelled so the first thing I have to do is label them. The box is labelled and this seems to be standard practice. Semaglutide is falling out of favour so I guess they're substituting. I have 4 years supply now so I guess I'll check back then and see where the market is at.
I know a bunch of people with multi-year stockpiles. I've got ~5 years of reta and ~6 years of tirz. This is too much, of course, but I determined a while back that under no circumstances do I ever intend to find myself unable to source it. My life is immeasurably better after losing 110 pounds.
It probably is, but that does not stop people from effectively doing it. There are a number of groups that specialize in conducting group buys, doing a bunch of testing on randomized samples, and then shipping out the product to individuals.
Also, if you plan to be on it a good long time, you can buy a bunch of kits yourself (a kit is 10 vials), run a bunch of tests, and then just have a nice stockpile that will last you years. The testing will likely cost as much or more than the product itself, but given how inexpensive the product is, you still come out way ahead financially.
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