I have used Little Snitch for quite a while, then switched to Hands Off because I liked its interface a bit better and the ability to set a rule that would clear at reboot was a win. I regularly block outgoing connections; tracking attempts by Google, Apple & Microsoft (no PowerPoint, you don't need to check in to Skype at each launch...), limiting a lot of apps to loopback connections rather than full outgoing connectivity, etc.
Another benefit is that once I get over the initial rule configuration hump (and it is a real PITA for the first week or two) what I end up seeing are the anomalies and so I can pay closer attention to what has changed or where something is trying to connect that I might want to think about.
Yeah, it was there but well hidden and an additional click with the mouse vs. being able to do it easily via keyboard. Small things like this really added up to push me to Hands Off, but I may give Little Snitch a look again if the price for upgrading from 2.0 is not unreasonable...
Another benefit is that once I get over the initial rule configuration hump (and it is a real PITA for the first week or two) what I end up seeing are the anomalies and so I can pay closer attention to what has changed or where something is trying to connect that I might want to think about.