A big thing I've done is use my multiplexer segregate contexts. When I spin up screen (tmux would work the same, just never switched) I set an environment variable noting the particular context I'm working in, and I adjust my PATH, HISTFILE, and more based on this variable.
I create new sessions and name them appropriately. My one wish is to be able to do "PREFIX ls" and then just hit enter on the session to switch to. I may be missing something, but I always have to do "PREFIX a -t [session name]".
