On platforms that support it, depending on how big the GC stalls are (extrapolation isn't magic) and it's not really something you should be triggering regularly by design. Async reprojection was invented to mitigate the fact that a variable frame rate makes you sick in VR so really it's evidence to support the parents case. If you're regularly dipping into async reprojection due to the GC then a trade off between visual accuracy/artifacts and the GC is being made.
No, it will be less noticeable in VR, because of asynchronous reprojection.