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Wasn't the amyloid-plaque etiology debunked recently?


Not debunked, just very much in question. A number of amyloid clearing drug trails have failed to achieve clinical progress on the disease in spite of clearing beta-amyloid.


I'll let Derek Lowe (of Things I Won't Work With/In the Pipeline fame) summarize it: https://blogs.sciencemag.org/pipeline/archives/2019/03/21/a-...

> Something is wrong with the way we’re thinking about Alzheimer’s and amyloid, folks, something is wrong. It’s been wrong for a long time and that’s been clear for a long time. Do something else.


From that summary it seems that amyloid may be an effect, not a cause, of Alzheimer's.




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