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Polio can definitely mutate to forms resistant to the vaccine. An outbreak in the Congo in 2010 resulted in 450 infections with a nearly 50% mortality rate. When scientists tested the strain on samples, they estimated that ~20+% of the population would still be susceptible in a fully vaccinated group. Not good..

https://en.ird.fr/the-media-centre/scientific-newssheets/464...



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