If you install Karabiner Elements[1] on macOS, all modifier keys suddenly work across all keyboards.
I'm using one "TKL" Apple USB keyboard per hand when I feel like opening my shoulders a bit. Took me all of two minutes to get used to, at a fraction of the cost for enthusiast keyboards. I wonder if there are any ergonomic advantages I'm missing out on.
(Karabiner Elements is a great tool, anyway; I've been using it for a long time to map Caps Lock to something useful for programming.)
problem is you'd then need to place them quite far apart from each other (while many of the "fixed" split keyboard have each half only slightly tilted) but... From an USB point of view I think this just works?