I use a lot of keyboard shortcuts. I can share what worked for me.

Remap CapsLock to Windows/Super. Mirror Ctrl and Alt from the left thumb cluster onto the right thumb cluster, so you have Ctrl and Alt in reach of each thumb.

Don't be afraid to customize special keys and punctuation. Especially that big Delete key under your left thumb. That's prime real estate.

If you have larger hands, buy some of the stick-on palm rest pads. They'll help bring your wrists to the right angles.