We have good results for c. elegans, mice, and fruit flies. These have all had their lifespans extended by quite a lot for c. elegans, or iirc about 40% for mice.
This, and the existence of several multicellular organisms that do not appear to age, is the basis for optimism for eventual success in extending healthspan. Like, so far we haven't found any fundamental biological reason that living longer is impossible.
(it is worth nothing that Blagosklonny's paradigm of programmed aging seems to me to lead to more pessimism, but I don't know if he'd agree)
Matt Kaeberlein's Dog Project, and Celine Halioua's company Loyal, are both focused on extending dog lifespan, as a much larger model organism, but are not there yet.
We have good results for c. elegans, mice, and fruit flies. These have all had their lifespans extended by quite a lot for c. elegans, or iirc about 40% for mice.
This, and the existence of several multicellular organisms that do not appear to age, is the basis for optimism for eventual success in extending healthspan. Like, so far we haven't found any fundamental biological reason that living longer is impossible.
(it is worth nothing that Blagosklonny's paradigm of programmed aging seems to me to lead to more pessimism, but I don't know if he'd agree)
Matt Kaeberlein's Dog Project, and Celine Halioua's company Loyal, are both focused on extending dog lifespan, as a much larger model organism, but are not there yet.
I also agree with your second paragraph :)