Maybe I misunderstood, but he said Coffescript's significant indentation solves Javascript's bloated syntax. I was just saying that code that uses significant indentation can't be minimized, as JS files often are.
http://bodil.github.com/coffeescript/#compress-slide
Doesn't matter either way. If you are in a production environment, using coffee-script would almost always involve a one-time compilation step to minified JS.
If you are sending real users coffee-script over the wire you are wasting a lot of their attention.