I've had depersonalization for over 10 years now after an incredibly intense experience from the first time I smoked weed(age 16.) Looking back I was a very anxious/depressed kid but theres no argument weed affected me in a very damaging and permanent manner.

I'm sure I would have been far more successful in life had I not smoked at all, but at the same time, I'm guessing I would have been much more narcissistic and judgemental towards people who struggle with mental illness. Win? Idk.

Had it been opiates instead of weed I probably would've died already.