I'm not sure about multiple cursors but for the large screen real estate problem some mice have a "precision" button that changes the DPI which can be leveraged. The intent is to make the DPI much lower while pressed (or toggled depending) but many allow you to set what DPI value you want it to use directly. This allows you to specify that the mouse will move say 4x as fast while you hold the precision button which is a lot less hand movement and coordination than switching over to another mouse.
Basically manual static acceleration for those that hate automatic smooth acceleration but want to occasional move fast easily.
Alternatively if you're lucky enough to have reasonably steady hands you'd be surprised what you can get used to as a default static speed. My multi-monitor setup is over 70 inches horizontally but I can get across it in a flick or still move pixel by pixel if I want.
Basically manual static acceleration for those that hate automatic smooth acceleration but want to occasional move fast easily.
Alternatively if you're lucky enough to have reasonably steady hands you'd be surprised what you can get used to as a default static speed. My multi-monitor setup is over 70 inches horizontally but I can get across it in a flick or still move pixel by pixel if I want.