You should! Not everyone wants to work as a cog in the giant enterprise machine. I've taken a lower salary from a small company specifically because they are small.

I would caution you against the "willing to sacrifice parts of their salary for 100% remote, flexible work time, PTO and others." mindset though. 100% remote, flexible work time, PTO, and other benefits are not added bonuses at this point: they are the minimum requirements for many positions/prospective employees. Instead, focus on the selling the qualities of your workplace that make people happy to work there (for instance, work/life balance, no red tape/micromanagement, creative freedom on solutions, interesting problems to solve, etc).

Why do you want to mislead these people in the first place? The advert has a role in filtering, and in turning down many people you are avoiding wasting time both for you and the potential candidate.

Give it a try. I've taken a lower paying job in exchange for a better experience. It happens!