"If you had two entangled quantum computers, one on Earth and the other in the Andromeda galaxy, and if they were both simulating [the wormhole], and if Alice on Earth and Bob in Andromeda both uploaded their own brains into their respective quantum simulations, then it seems possible that the simulated Alice and Bob could have the experience of jumping into a wormhole and meeting each other in the middle. ... if true, I suppose some would treat it as grounds for regarding a quantum simulation of SYK as “more real” or “more wormholey” than a classical simulation."
I think you may have missed the point. Aaronson is being ironic here. Uploading your brain into a quantum simulation is ridiculously far beyond the realm of plausibility. He's not suggesting this as an actual scenario, he's saying "This wormhole claim requires so much suspension of disbelief that you have to be profoundly ignorant of how quantum computers actually work in order to lend it any credence at all."
"If you had two entangled quantum computers, one on Earth and the other in the Andromeda galaxy, and if they were both simulating [the wormhole], and if Alice on Earth and Bob in Andromeda both uploaded their own brains into their respective quantum simulations, then it seems possible that the simulated Alice and Bob could have the experience of jumping into a wormhole and meeting each other in the middle. ... if true, I suppose some would treat it as grounds for regarding a quantum simulation of SYK as “more real” or “more wormholey” than a classical simulation."