Half conventional HPC simulation that runs best on CPU, half Neural Networks that need GPUs. As proposed for example here

https://www.nature.com/articles/s41586-019-0912-1

and here

https://www.nature.com/articles/s42256-021-00374-3

> The next step will be a hybrid modelling approach, coupling physical process models with the versatility of data-driven machine learning.

The Frontier HPC system that AMD just delivered is aimed fully at that problem.

https://en.wikipedia.org/wiki/Frontier_(supercomputer)