The problem with Airflow is that each step of the DAG for a bioinformatics workflow is generally going to be running a command line tool. And it'll expect files to have been staged in and living in the exact right spot. And it'll expect files to have been staged out from the exact right spot.

This can all be done with Airflow, but the bioinformatics workflow engines understand that this is a first class use case for these users, and make it simpler.