I really like the idea. My only nitpick is that these days most projects seem to be ending up as jQuery plugins even when they don't really use much of its functionality. I think a standalone version would save a bit of effort for some of us bound to other frameworks (or not using any framework).
I'm not going to lose sleep over adding a JQuery dependency. The fact is it gets you code that targets 95% of browsers with no hacks. I don't want to code explicitly for IE6-8, and JQuery gets me a lot of functionality on those browsers for free. Sure, there may be other frameworks, and sure, JQuery has its faults, and sure, a framework seems like overkill. But I feel a lot more sure about the functionality of my code when I'm relying on a broadly tested cross-browser suite.
The source is available and the license allows for derivatives. Would you be interested in forking the code and putting together a plain-javascript version?
No, sorry, I'm not much of an Javascript programmer, neither am I that interested. I realize my post kind of looks like standard wankery-won't-work-himself; I was replying specifically to lukeschlather only regarding whether a jquery dependency is advisable.
I totally hear you. The jQuery plugin actually wraps Kicksend.mailcheck, so it's easily decoupled (do fork it!). Since its main use would be on the client side, we released as a plugin for the ease of adoption.