Economy and psychology aren't too dissimilar when it comes to being "real" science. People can think whatever they want about genders, dismissing hormones is a bit harder, especially when people fight to get said hormones to affirm their gender, if it was all "the same" and interchangeable it wouldn't be the case
I've been surgically modified such that my body doesn't produce sex hormones in any significant quantity on its own. As a substitute, I use separate transdermal gels containing testosterone and estrogen, which have relatively short metabolic half life in my body.
I normally target an estrogen level similar to an average woman and a testosterone level between the female and male reference ranges. I'm able to adjust the mix on the order of days when it suits me, and there absolutely is a difference. People who know me well can usually tell what mix I'm running.
