You take a little performance hit upon initial startup (from a clean filesystem, while __pycache__ folders are created). Other than that, mostly everything is the same.

I'm now figuring out how to pack images to OpenAI REST calls (using my own REST wrapper), and everything is peachy. Here's my test snippet (mostly to b64encode the file):

    (import aiohttp [ClientSession]
            base64  [b64encode]
            asyncio [run])

    (defn :async pack-image [filename]
      (with [h (open filename "rb")]
        {
          "type" "image_url"
          "image_url" { "url" f"data:image/jpeg;base64,{(.decode (b64encode (.read h)) "utf-8")}" }
        }))

    (defn :async main[]
      (print (await (pack-image "request.hy"))))

    (run (main))

This shows you async, context managers, selective imports, f-strings... etc. All that you need, really.