I had the idea to use an ozone generator in my car once but backed off due to a concern about it degrading interior rubbers and plastics. I guess that's not much of a real concern in practice though.

It's a mild concern, but if you need enough ozone to cause meaningful damage then the smoke has probably ruined the car anyway. The key is to run it just barely long enough.

In my case the smell came from running over a rotten deer carcass. I settled on about a dozen trips through an undercarriage carwash them leaving the windows all open for a month. I figured the smell would go away eventually so I wasn't eager to risk long term damage from ozone, but my god was the smell awful for the first week.

If you don't overdo it (like the guy in the reddit post did), it works great. 5 to 10 minutes with the car fan recirculating the air, repeat once or twice if needed. Just make sure you don't breathe the ozone.

I have been dealing with a moldy furnace caused by AC condensate overflow. I bought a small ozone generator. It had a timer for up to two hours or an indefinite on button. I was leaving for the weekend and wanted it to run for a while. I had planned to run it for the entire two days I'd be gone. I bought 3M organic vapor filters so I could go back into the house and crack open windows when I returned just in case. I would have taken the panel off the furnace and just run the generator inside the enclosed utility room. I continued to do some more reading and found that I likely would have destroyed all of the insulation on the wiring inside the furnace along with anything else plastic in that room and likely nearby rooms. Instead, I just ran it for the max two hours immediately after I left the house. Everything was fine when I got back but the furnace still smelled a bit.

5-10 minutes might get a bad fart out, but any real amount of cigarette smoking is going to take a few hours of cooking.

The lesson from the thread is to start small and work your way up, instead of just nuking it.

In the aforementioned youtube video, he mentions that his ozone generator automatically cycles, running for a few minutes every hour. That's probably how he was able to leave it running for several days with no issues, at least compared to the guy in the reddit thread.

I’ve used Simple Green to remove nicotine before. In a house you can also paint over it with shellac primer.