No, weight is just mass plus some sort of acceleration, if there's something to substitute gravity everything would be well, the main problem is with body fluids, we evolved to deal with earth surface level of gravity, in the interplanetary space I do not see how centrifugal acceleration is possible unless it's something that the spaceship do to generate it, from what I know this is hard and do not see solved in the foreseeable future. I would love to be wrong.