Would it make sense to apply to YC (or to one of its recent imitators) with an open-source project?
If not, then why?
It might be a weird idea, but after all, an open-source project makes something people want, it has leverage, and it can sure use some money.
So can anyone give a good reason why this will not work?
Simulation is not exactly sales automation, data capture, billing or inventory.
Your best bet is to reach out to federal safety and security agency, and sell them a heavily customized version of the tool (usually the problem du jour; few years ago was terrorism, now it's home foreclosure, job loses, etc.) you will be prepared to have a few PhDs on board to sell it to the governments and you might need to reach out to your local governments and municipalities.